Christina was the assistant to Professor Canaris, who was attacked by a werewolf in the woods. She became a werewolf when Canaris attacked her, and she went to the Daily Planet with video evidence of the werewolf sighting. Christina and Clark Kent went to Canaris' office, where Canaris appeared in his werewolf form and fought with him after he morphed into Superboy. Christina disappeared during the melee, but unbeknownst to Clark, she transformed into a werewolf and killed an unknown victim, establishing Christina as a heel. Christina wanted Canaris killed hoping that her curse would be lifted, and he was killed during his fight with Superboy.
Believing that her werewolf curse was lifted, Christina went on a date with Clark, only to see hair on her hands when the full moon appeared. She ran off to the restroom, where she saw more hair on her face, and rushed to a stall to complete her transformation. Christina turned villainous once again and went on a rampage in her werewolf form. Superboy enters and fights the evil Werewolf Christina, and later learns of her true identity. Christina runs off, but Superboy powers down and follows her. Clark attempted to get through to Christina, but she lunges after him right before she is shot and killed by TJ, finally freeing her from her curse.