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Gabriel Van Helsing is a legendary hunter of monsters and enemy of Count Dracula in Van Helsing (2004). Helsing temporarily became an omega wolf after being bit by Velkan, The Wolf Man.

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In 1887 Transylvania, The Wolf Man ambushes and bites Van Helsing. Carl, a friar who provides Van Helsing with aid and weapons, determines that the bite of the Wolf Man is the only way to kill Dracula. As the Wolf Man, Van Helsing and Dracula do battle, Van Helsing turns into a werewolf and bites Dracula, who then dissolves into a skeleton. Van Helsing is delivered a cure for lycanthropy, and returns to being human.