While driving through Vermont, New England, the middle age chief editor Will Randall hits a wolf with his car. He stops the car to drag the animal out of the road, but the wolf is alive and bites his hand. He goes to the doctor, takes a rabies vaccine and the doctor releases him. Will is under stress in his job since the publishing house where he works has been bought by the tough millionaire Raymond Alden and the employees are expecting downsizing. Will is supported by his wife Charlotte Randall and his colleague and assistant Stewart Swinton. Raymond invites Will to a party at his manor and he offers an unwanted job position in Eastern Europe to him and he learns that he had been betrayed by Stewart, who will occupy his position in the publishing house. Will also meets Raymond's rebel daughter Laura Alden. On the next morning, Will Randall goes to his work and learns that he has acute senses and he feels more competitive and decided to fight for his job. Further he discovers that Charlotte is cheating on him with Stewart and that Laura and he are in love with each other. But Will Randall is becoming a wolf and his transformation completely changes his life.